Lucky Star is about four girls going through high school in Japan. The contrasting personalities of the girls (otaku, studious, tsundere, and bonkura) make for well-balanced humor. It is a very light-hearted anime but it does better than other adaptions of four-panel manga in that it fills in what space would be between strips with its own content.
The English adaption of the manga, at least in the editions I own, was not well translated. I usually encourage the use of Japanese terms without any real english translation–like tsundere and moe–in any manga. The editor, translator, and letterer for the English version were all lacking. The manga contain multiple typos and errors that tend to detract from the overall experience at times. If you are a fan of the anime, though, I suggest you hunt down a copy. The strips are artfully illustrated and witty. Towards the end of the series, the volumes contain more and more strips that were used in advertisements for other series and feel like filler material.
Think before you go out to buy the manga–it is now out of print in the U.S. and not cheap! But definitely worth it if you are a fan.